IKZF1 FISH Probe
Our IKZF1 probe is designed to detect IKZF1 amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| IKZF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| IKZF1-20-RE | 20 (40 μL) | 200 μL |
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| IKZF1-20-AQ | 20 (40 μL) | 200 μL |
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| IKZF1-20-GR | 20 (40 μL) | 200 μL |
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| IKZF1-20-GO | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: IKZF1
Gene Name: IKAROS Family Zinc Finger 1
Chromosome: CHR7: 50344377-50472798
Locus: 7p12.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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