Empire Genomics | Clinical FISH Probe Panels

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FISH Probe Panels

Making New Disease Specific Discoveries

Empire Genomics FISH probe panels are designed to hybridize to the precise location of genes associated with a specific disease and contain multiple RP11 clones to produce a strong signal. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads. Disease specific probes are available in both single and dual colors. These products are for research use only (RUO) and are not for use in diagnostic procedures.

AneuFocus

Our AneuFocus kit is used to identify chromosome 13, 18, 21, X and Y aneusomy, which collectively account for the vast majority of clinically significant karyotype alterations in both prenatal cases and newborns.

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FGFR Panel

FGFR 1, 2, 3 and 4 are tyrosine kinase receptors involved in numerous intracellular signaling pathways. FGFR alterations promote disease progression in several different cancers. Our FGFR panel offers probes for detecting these abnormalities.

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IGH Reflex

Our IGH Reflex Panel is designed to detect major IGH fusions found in multiple myeloma (MM). Following detection of an IGH translocation, these probes are ideal for testing for the presence of 4 common IGH fusion partners specific to MM.

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Multiple Myeloma FISH Panel

Multiple myeloma is the end result of several precursor conditions that are triggered by abnormal proliferation of plasma cells. Patients can display a diverse array of genetic alterations, which have been shown to correlate with different disease stages.

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NTRK Panel

The NTRK gene family encodes receptors that regulate multiple pathways crucial to nervous system development. NTRK fusions, which generate chimeric proteins with unchecked NTRK signaling, have emerged as disease drivers across a range of cancers.

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PDL Panel

Malignant cells have been shown to overexpress PD-L1 and PD-L2 receptors on their surface in order to escape T-cell destruction. Our PD-L FISH panel offers probes to detect PD-L1 and PD-L2 gene amplification.

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Renal Cell Carcinoma

Renal cell carcinoma (RCC) is the most frequently diagnosed kidney cancer. The disease is clinically and genetically heterogeneous, with a diverse range of subtypes that all stem from abnormal cell proliferation in the tubule linings of the kidneys. A variety of genes have been implicated in RCC oncogenesis. Empire Genomics'...

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