ERG/TMPRSS2 Deletion/Break Apart FISH Probe
Our ERG/TMPRSS2 deletion/break apart probe is designed to detect the deletion between TMPRSS2 and ERG (which leads to TMPRSS2/ERG fusion), as well as translocations involving the TMPRSS2 region. The probe comes labeled in aqua, green, and orange, but can be customized to meet your needs.
Gene Background: TMPRSS2 is a prostate‑specific, androgen-response gene that encodes a serine protease. The gene has been shown to drive prostate carcinogenesis via fusion with ETS transcription factors, especially ERG and ETV1. ERG is an oncogene that encodes an erythroblast transformation‑specific transcription factor, a central monitor of cell proliferation, differentiation, angiogenesis, inflammation and apoptosis. TMPRSS2-ERG fusion is the most common genetic aberration in prostate cancer, occurring in > 50% of cases. The fusion results in overexpression of ERG, which isn’t normally expressed in prostate epithelia, and likely contributes to disease development by promoting tumor angiogenesis.
Source: Wang Z, et al. (2017) Molec medicine reports 16.4: 5450-5458.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ERG-TMPRSS2-20-AQGROR (Standard Design) | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQGRGO | 20 (40 μL) | 200 μL |
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| ERG-TMPRSS2-20-AQGRRE | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Details
Gene Symbol: ERG
Gene Name: ERG, ETS Transcription Factor
Chromosome: CHR21: 39739182-40033618
Locus: 21q22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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