KAT6A-CREBBP Fusion FISH probe
Our KAT6A/CREBBP fusion probe is designed to detect fusions between KAT6A and CREBBP. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: KAT6A codes for a zinc finger protein that regulates transcription via activation of RUNX1, while CREBBP encodes a ubiquitously expressed protein that monitors central cell cycle functions. The t(8;16)(p11;p13) rearrangement generates the KAT6A/CREBBP fusion, a rare but recurrent abnormality found in approximately 0.2-0.4% of acute myeloid leukemia (AML) patients. As of 2019, only about 100 cases of KAT6A/CREBBP-positive AML had been reported, mostly as single case reports. The abnormality is more common in therapy-related and neonatal AML.
Source: Xie W, t al. (2019) Annals of hematology 98.5: 1149-1157.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KAT6A-CREBBP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KAT6A-CREBBP-20-GOGR | 20 (40 μL) | 200 μL |
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| KAT6A-CREBBP-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Details
Gene Symbol: KAT6A
Gene Name: Lysine Acetyltransferase 6A
Chromosome: CHR8: 41786996-41909505
Locus: 8p11.21
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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