PBX1/TCF3 Fusion FISH Probe
Our PBX1/TCF3 fusion probe is designed to detect fusions between PBX1 and TCF3. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: PBX1-TCF3 fusion is one of the most prevalent rearrangements in B-ALL, occurring in about 6% of adult and childhood patients. The fusion is generated by either the balanced t(1;19)(q23;p13) or the unbalanced der(19)t(1;19)(q23;p13) translocation. Its encoded protein is a transcription factor bearing the transactivation domain of TCF3 and the DNA-binding domain of PBX1, resulting in constitutive activation of PBX1-bound proteins.
Source: Tirado C, et al. (2015) Biomarker research. 3.1: 4.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PBX1-TCF3-20-ORGR | 20 (40 μL) | 200 μL |
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| PBX1-TCF3-20-GOGR | 20 (40 μL) | 200 μL |
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| PBX1-TCF3-20-REGR | 20 (40 μL) | 200 μL |
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| PBX1-TCF3-20-REAQ | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Gene Details
Gene Symbol: PBX1
Gene Name: PBX Homeobox 1
Chromosome: CHR1: 164528596-164821060
Locus: 1q23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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