FUS/ERG Fusion FISH Probe
Our FUS/ERG fusion probe is designed to detect fusions between FUS and ERG. The probe comes labeled in orange and green, but can be customized to meet your needs.
Gene Background: FUS encodes an RNA-binding protein that monitors RNA splicing, while ERG encodes a transcription factor of the ETS oncogene superfamily.1 FUS/ERG fusion generates a chimeric oncogene with the N-terminal domain of FUS and the ETS motif-DNA-binding domain of ERG.2 The fusion is found in about 1% of acute myeloid leukemia (AML) patients.2 Because ERG has been shown to form a homologous fusion with the EWS gene in Ewing sarcoma (ES), it’s been hypothesized that FUS/ERG fusion drives AML progression in much the same way as EWS/ERG in ES – that is, by acting as a transcriptional activator that contributes to overexpression of various oncogenes.1
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| FUS-ERG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| FUS-ERG-20-GOGR | 20 (40 μL) | 200 μL |
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| FUS-ERG-20-REGR | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Gene Details
Gene Symbol: FUS
Gene Name: FUS RNA Binding Protein
Chromosome: CHR16: 31191430-31206192
Locus: 16p11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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