EGLN1 FISH Probe
Mutations in the EGLN1 gene, located on chromosome 1q42.2, are categorized by loss of catalytic function and abnormal erythropoietin expression, as well as association with erythrocytosis familial type 3 (ECYT3). Overexpression and nuclear translocation in EGLN1 have been associated with aggressive head and neck carcinomas. Other associated cancers include pheochromocytoma, adrenocortical cancer, breast cancer, kidney cancer, and cervical cancer.
Empire Genomics has developed a EGLN1 FISH Probe assay which can be used to detect EGLN1 gene aneusomy. The probe comes labeled in orange, and you may also choose to customize the probe to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EGLN1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| EGLN1-20-GO | 20 (40 μL) | 200 μL |
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| EGLN1-20-GR | 20 (40 μL) | 200 μL |
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| EGLN1-20-AQ | 20 (40 μL) | 200 μL |
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| EGLN1-20-RE | 20 (40 μL) | 200 μL |
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Gene Summary
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
Gene Details
Gene Symbol: EGLN1
Gene Name: Egl-9 Family Hypoxia Inducible Factor 1
Chromosome: CHR1: 231499496-231560790
Locus: 1q42.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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