MDM4 FISH Probe
The MDM4 gene, located at chromosome 1q32.1, is a P53 regulator gene that follows a similar pathway to MicroRNAs in cancer. P53 is a tumor suppressor protein that is frequently mutated. When MDM4 is overexpressed it makes P53 more attractive targets for mutation. Overexpression and mutation of MDM4 is associated with breast cancer, soft tissue sarcoma, retinoblastoma, and glioblastoma.
Empire Genomics has developed a MDM4 FISH Probe which can be used to detect MDM4 gene aneusomy. The probe comes labeled in green, and you may also choose to customize the probe to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM4-20-GO | 20 (40 μL) | 200 μL |
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| MDM4-20-GR | 20 (40 μL) | 200 μL |
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| MDM4-20-AQ | 20 (40 μL) | 200 μL |
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| MDM4-20-RE | 20 (40 μL) | 200 μL |
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Gene Summary
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: MDM4
Gene Name: MDM4, P53 Regulator
Chromosome: CHR1: 204485506-204527248
Locus: 1q32.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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