ROS1 FISH Probe

The ROS1 proto-oncogene encodes a protein with tyrosine kinase activity. This protein is highly expressed in several tumor types. The protein may function as a growth or differentiation factor receptor. Chromosomal rearrangements involving the ROS1 gene were originally described in glioblastomas. More recently, ROS1 rearrangements have been identified as a potential "driver" mutation in non-small cell lung cancer and cholangiocarcinoma. Empire Genomics has developed a custom ROS1 probe which can be used to detect/confirm a rearrangement of the ROS1 gene. The probe comes labeled in orange, and you may also choose to customize the probe to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

• Product Details
• Gene Details
• Protocols
• Customer Publications (1)

SKU	Test Kits	Buffer	Dye Color	Order Now
ROS1-20-OR  (Standard Design)	20 (40 μL)	200 μL		View Pricing
ROS1-20-RE	20 (40 μL)	200 μL		View Pricing
ROS1-20-AQ	20 (40 μL)	200 μL		View Pricing
ROS1-20-GR	20 (40 μL)	200 μL		View Pricing
ROS1-20-GO	20 (40 μL)	200 μL		View Pricing

Gene Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: ROS1

Gene Name: ROS Proto-oncogene 1, Receptor Tyrosine Kinase

Chromosome: CHR6: 117609529-117747018

Locus: 6q22.1

FISH Probe Protocols

Protocol, Procedure, or Form Name	Last Modified	Download

Comprehensive Genomic Profiling of Malignant Effusions in Patients with Metastatic Lung Adenocarcinoma

In this study, the utility of performing targeted next-generation sequencing (NGS) on malignant effusions from patients with metastatic lung adenocarcinoma was investigated. NGS is a high throughput technology, which utilizes a small sample input, but the suitability of NGS analysis for tissue-free cytology samples such as malignant body fluids is not well understood. In order to investigate the adequacy of NGS on liquid biopsies of MLA, targeted NGS was performed using custom target panels consisting of many oncogenes. Additional non-NGS molecular tests were performed on the effusion samples, including fluorescence in situ hybridization (FISH) analysis for the oncogene ROS1, using a break-apart FISH probe manufactured by Empire Genomics.

Read More