SEARCH OUR PRODUCT CATALOG

FISH Probe Products & Services
Request More Information

KRAS FISH Probe

Our KRAS probe is designed to detect KRAS amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
KRAS-20-OR  (Standard Design) 20 (40 μL) 200 μL
KRAS-20-RE 20 (40 μL) 200 μL
KRAS-20-AQ 20 (40 μL) 200 μL
KRAS-20-GR 20 (40 μL) 200 μL
KRAS-20-GO 20 (40 μL) 200 μL

Gene Summary

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: KRAS

Gene Name: KRAS Proto-oncogene, GTPase

Chromosome: CHR12: 25358179-25403854

Locus: 12p12.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

A Clinicopathologic and Molecular Analysis of 34 Mediastinal Germ Cell Tumors Suggesting Different Modes of Teratoma Development

Mediastinal teratomas can be both malignant and benign. Increased 12p copy numbers are uniform in malignant testicular germ cell tumors (GCT), so the 12p copy numbers were analyzed in mediastinal GCTs to see if this is indicative of malignancy. FISH analysis was used with our KRAS and chromosome 12 centromere probes to look for 12p copy number increases. The sensitivity for increased 12p copies for malignant GCT was 69%. This is less than reports for other tumors, and a negative test for increased 12p copies should not necessarily rule out malignancy.
Read More