ZP3 FISH Probe
The ZP3 FISH probe is designed to hybridize to the ZP3 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ZP3-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| ZP3-20-RE | 20 (40 μL) | 200 μL |  |
|
| ZP3-20-GO | 20 (40 μL) | 200 μL |  |
|
| ZP3-20-GR | 20 (40 μL) | 200 μL |  |
|
| ZP3-20-AQ | 20 (40 μL) | 200 μL |  |
|
| ZP3-20-DIG | 20 (40 μL) | 200 μL |  |
|
| ZP3-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: ZP3
Gene Name: Zona Pellucida Glycoprotein 3
Chromosome: CHR7: 76026840-76071388
Locus: 7q11.23
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: ZP3 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: ZP3-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping