UBE3A FISH Probe
The UBE3A FISH probe is designed to hybridize to the UBE3A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| UBE3A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| UBE3A-20-RE | 20 (40 μL) | 200 μL |  |
|
| UBE3A-20-GO | 20 (40 μL) | 200 μL |  |
|
| UBE3A-20-GR | 20 (40 μL) | 200 μL |  |
|
| UBE3A-20-AQ | 20 (40 μL) | 200 μL |  |
|
| UBE3A-20-DIG | 20 (40 μL) | 200 μL |  |
|
| UBE3A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: UBE3A
Gene Name: Ubiquitin Protein Ligase E3A
Chromosome: CHR15: 25582395-25684175
Locus: 15q11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: UBE3A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: UBE3A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping