TCRAV2S1 FISH Probe
The TCRAV2S1 FISH probe is designed to hybridize to the TCRAV2S1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRAV12-2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TRAV12-2-20-RE | 20 (40 μL) | 200 μL |  |
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| TRAV12-2-20-GO | 20 (40 μL) | 200 μL |  |
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| TRAV12-2-20-GR | 20 (40 μL) | 200 μL |  |
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| TRAV12-2-20-AQ | 20 (40 μL) | 200 μL |  |
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| TRAV12-2-20-DIG | 20 (40 μL) | 200 μL |  |
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| TRAV12-2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]
Gene Details
Gene Symbol: TRAV12-2
Gene Name: T Cell Receptor Alpha Variable 12-2
Chromosome: CHR14: 21887958-21888501
Locus: 14q11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TCRAV2S1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TRAV12-2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping