TBP FISH Probe
The TBP FISH probe is designed to hybridize to the TBP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TBP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| TBP-20-RE | 20 (40 μL) | 200 μL |  |
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| TBP-20-GO | 20 (40 μL) | 200 μL |  |
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| TBP-20-GR | 20 (40 μL) | 200 μL |  |
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| TBP-20-AQ | 20 (40 μL) | 200 μL |  |
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| TBP-20-DIG | 20 (40 μL) | 200 μL |  |
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| TBP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Gene Details
Gene Symbol: TBP
Gene Name: TATA-box Binding Protein
Chromosome: CHR6: 170863420-170881958
Locus: 6q27
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: TBP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TBP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping