SPHK1 FISH Probe
The SPHK1 FISH probe is designed to hybridize to the SPHK1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SPHK1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SPHK1-20-RE | 20 (40 μL) | 200 μL |  |
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| SPHK1-20-GO | 20 (40 μL) | 200 μL |  |
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| SPHK1-20-GR | 20 (40 μL) | 200 μL |  |
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| SPHK1-20-AQ | 20 (40 μL) | 200 μL |  |
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| SPHK1-20-DIG | 20 (40 μL) | 200 μL |  |
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| SPHK1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Gene Details
Gene Symbol: SPHK1
Gene Name: Sphingosine Kinase 1
Chromosome: CHR17: 74380689-74383941
Locus: 17q25.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SPHK1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SPHK1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping