SHC1 FISH Probe
The SHC1 FISH probe is designed to hybridize to the SHC1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
SKU | Test Kits | Buffer | Dye Color | Order Now |
---|---|---|---|---|
SHC1-20-OR (Standard Design) | 20 (40 μL) | 200 μL | ||
SHC1-20-RE | 20 (40 μL) | 200 μL | ||
SHC1-20-GO | 20 (40 μL) | 200 μL | ||
SHC1-20-GR | 20 (40 μL) | 200 μL | ||
SHC1-20-AQ | 20 (40 μL) | 200 μL | ||
SHC1-20-DIG | 20 (40 μL) | 200 μL | ||
SHC1-20-BIO | 20 (40 μL) | 200 μL |
Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Details
Gene Symbol: SHC1
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773-154946959
Locus: 1q21.3
FISH Probe Protocols
Protocol, Procedure, or Form Name | Last Modified | Download |
---|
Customer Publications
Product Details
Product: SHC1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SHC1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping