SENP6 FISH Probe
The SENP6 FISH probe is designed to hybridize to the SENP6 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SENP6-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| SENP6-20-RE | 20 (40 μL) | 200 μL |  |
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| SENP6-20-GO | 20 (40 μL) | 200 μL |  |
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| SENP6-20-GR | 20 (40 μL) | 200 μL |  |
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| SENP6-20-AQ | 20 (40 μL) | 200 μL |  |
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| SENP6-20-DIG | 20 (40 μL) | 200 μL |  |
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| SENP6-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Details
Gene Symbol: SENP6
Gene Name: SUMO1/sentrin Specific Peptidase 6
Chromosome: CHR6: 76311621-76427994
Locus: 6q14.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: SENP6 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: SENP6-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping