RP1 FISH Probe
The RP1 FISH probe is designed to hybridize to the RP1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RP1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RP1-20-RE | 20 (40 μL) | 200 μL |  |
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| RP1-20-GO | 20 (40 μL) | 200 μL |  |
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| RP1-20-GR | 20 (40 μL) | 200 μL |  |
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| RP1-20-AQ | 20 (40 μL) | 200 μL |  |
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| RP1-20-DIG | 20 (40 μL) | 200 μL |  |
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| RP1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Transcript variants resulted from an alternative promoter and alternative splicings have been found, which overlap the current reference sequence and has several exons upstream and downstream of the current reference sequence. However, the biological validity and full-length nature of some variants cannot be determined at this time.[provided by RefSeq, Sep 2010]
Gene Details
Gene Symbol: RP1
Gene Name: RP1, Axonemal Microtubule Associated
Chromosome: CHR8: 55528626-55543394
Locus: 8q11.23-q12.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RP1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RP1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping