RNTMI FISH Probe
The RNTMI FISH probe is designed to hybridize to the RNTMI gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| TRX-CAT2-1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| TRX-CAT2-1-20-RE | 20 (40 μL) | 200 μL |  |
|
| TRX-CAT2-1-20-GO | 20 (40 μL) | 200 μL |  |
|
| TRX-CAT2-1-20-GR | 20 (40 μL) | 200 μL |  |
|
| TRX-CAT2-1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| TRX-CAT2-1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| TRX-CAT2-1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Santos and Zasloff (1981) [PubMed 6261953] identified 12 initiator methionine tRNA genes, symbolized tRNA-i(met), in the haploid human genome. Zasloff et al. (1982) [PubMed 6923137] found a variant tRNA-i(met) with a G-to-T transversion in the highly conserved TCGA sequence in loop 4, a sequence position occupied exclusively by a purine (usually G) in almost 200 prokaryotic and eukaryotic tRNAs. One functional consequence of this base substitution is reduction in the rate of processing of the primary transcript of the gene. A second, demonstrated by microinjection into the germinal vesicle of the intact Xenopus laevis oocyte, is blockage of egress from the nucleus. It has been estimated that the human haploid genome contains 1,000 to 2,000 tRNA genes and that there are 50 to 60 chromatographically distinct tRNA species. These observations suggest redundancy of some tRNA genes. The studies of initiator methionine tRNA genes bear out this suspicion.[supplied by OMIM, Sep 2009]
Gene Details
Gene Symbol: TRX-CAT2-1
Gene Name: Transfer RNA-iMet (CAT) 2-1
Chromosome: CHR6: 27777884-27777955
Locus: 6p22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: RNTMI FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: TRX-CAT2-1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping