RAF1 FISH Probe
The RAF1 FISH probe is designed to hybridize to the RAF1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
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| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RAF1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| RAF1-20-RE | 20 (40 μL) | 200 μL |  |
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| RAF1-20-GO | 20 (40 μL) | 200 μL |  |
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| RAF1-20-GR | 20 (40 μL) | 200 μL |  |
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| RAF1-20-AQ | 20 (40 μL) | 200 μL |  |
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| RAF1-20-DIG | 20 (40 μL) | 200 μL |  |
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| RAF1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: RAF1
Gene Name: Raf-1 Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR3: 12625099-12705700
Locus: 3p25.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: RAF1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: RAF1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping