PSMB11 FISH Probe
The PSMB11 FISH probe is designed to hybridize to the PSMB11 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PSMB11-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PSMB11-20-RE | 20 (40 μL) | 200 μL |  |
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| PSMB11-20-GO | 20 (40 μL) | 200 μL |  |
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| PSMB11-20-GR | 20 (40 μL) | 200 μL |  |
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| PSMB11-20-AQ | 20 (40 μL) | 200 μL |  |
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| PSMB11-20-DIG | 20 (40 μL) | 200 μL |  |
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| PSMB11-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]
Gene Details
Gene Symbol: PSMB11
Gene Name: Proteasome Subunit Beta 11
Chromosome: CHR14: 23511375-23513269
Locus: 14q11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PSMB11 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PSMB11-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping