PSENEN FISH Probe
The PSENEN FISH probe is designed to hybridize to the PSENEN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PSENEN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| PSENEN-20-RE | 20 (40 μL) | 200 μL |  |
|
| PSENEN-20-GO | 20 (40 μL) | 200 μL |  |
|
| PSENEN-20-GR | 20 (40 μL) | 200 μL |  |
|
| PSENEN-20-AQ | 20 (40 μL) | 200 μL |  |
|
| PSENEN-20-DIG | 20 (40 μL) | 200 μL |  |
|
| PSENEN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Details
Gene Symbol: PSENEN
Gene Name: Presenilin Enhancer Gamma-secretase Subunit
Chromosome: CHR19: 36236493-36237903
Locus: 19q13.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: PSENEN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PSENEN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping