PPP1R15B FISH Probe
The PPP1R15B FISH probe is designed to hybridize to the PPP1R15B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPP1R15B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPP1R15B-20-RE | 20 (40 μL) | 200 μL |  |
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| PPP1R15B-20-GO | 20 (40 μL) | 200 μL |  |
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| PPP1R15B-20-GR | 20 (40 μL) | 200 μL |  |
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| PPP1R15B-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPP1R15B-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPP1R15B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
Gene Details
Gene Symbol: PPP1R15B
Gene Name: Protein Phosphatase 1 Regulatory Subunit 15B
Chromosome: CHR1: 204372491-204380944
Locus: 1q32.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPP1R15B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPP1R15B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping