PPP1R12A FISH Probe
The PPP1R12A FISH probe is designed to hybridize to the PPP1R12A gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPP1R12A-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPP1R12A-20-RE | 20 (40 μL) | 200 μL |  |
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| PPP1R12A-20-GO | 20 (40 μL) | 200 μL |  |
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| PPP1R12A-20-GR | 20 (40 μL) | 200 μL |  |
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| PPP1R12A-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPP1R12A-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPP1R12A-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Details
Gene Symbol: PPP1R12A
Gene Name: Protein Phosphatase 1 Regulatory Subunit 12A
Chromosome: CHR12: 80167342-80329235
Locus: 12q21.2-q21.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPP1R12A FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPP1R12A-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping