PPM1F FISH Probe
The PPM1F FISH probe is designed to hybridize to the PPM1F gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PPM1F-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PPM1F-20-RE | 20 (40 μL) | 200 μL |  |
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| PPM1F-20-GO | 20 (40 μL) | 200 μL |  |
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| PPM1F-20-GR | 20 (40 μL) | 200 μL |  |
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| PPM1F-20-AQ | 20 (40 μL) | 200 μL |  |
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| PPM1F-20-DIG | 20 (40 μL) | 200 μL |  |
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| PPM1F-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: PPM1F
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1F
Chromosome: CHR22: 22273791-22307250
Locus: 22q11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PPM1F FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PPM1F-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping