POMC FISH Probe
The POMC FISH probe is designed to hybridize to the POMC gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| POMC-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| POMC-20-RE | 20 (40 μL) | 200 μL |  |
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| POMC-20-GO | 20 (40 μL) | 200 μL |  |
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| POMC-20-GR | 20 (40 μL) | 200 μL |  |
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| POMC-20-AQ | 20 (40 μL) | 200 μL |  |
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| POMC-20-DIG | 20 (40 μL) | 200 μL |  |
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| POMC-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
Gene Details
Gene Symbol: POMC
Gene Name: Proopiomelanocortin
Chromosome: CHR2: 25383721-25391559
Locus: 2p23.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: POMC FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: POMC-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping