PFKFB4 FISH Probe
The PFKFB4 FISH probe is designed to hybridize to the PFKFB4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PFKFB4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PFKFB4-20-RE | 20 (40 μL) | 200 μL |  |
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| PFKFB4-20-GO | 20 (40 μL) | 200 μL |  |
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| PFKFB4-20-GR | 20 (40 μL) | 200 μL |  |
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| PFKFB4-20-AQ | 20 (40 μL) | 200 μL |  |
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| PFKFB4-20-DIG | 20 (40 μL) | 200 μL |  |
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| PFKFB4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Details
Gene Symbol: PFKFB4
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Chromosome: CHR3: 48555116-48594227
Locus: 3p21.31
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PFKFB4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PFKFB4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping