PDF FISH Probe
The PDF FISH probe is designed to hybridize to the PDF gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDF-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PDF-20-RE | 20 (40 μL) | 200 μL |  |
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| PDF-20-GO | 20 (40 μL) | 200 μL |  |
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| PDF-20-GR | 20 (40 μL) | 200 μL |  |
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| PDF-20-AQ | 20 (40 μL) | 200 μL |  |
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| PDF-20-DIG | 20 (40 μL) | 200 μL |  |
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| PDF-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq, Nov 2008]
Gene Details
Gene Symbol: PDF
Gene Name: Peptide Deformylase, Mitochondrial
Chromosome: CHR16: 69362523-69364498
Locus: 16q22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PDF FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PDF-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping