PCSK9 FISH Probe
The PCSK9 FISH probe is designed to hybridize to the PCSK9 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PCSK9-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PCSK9-20-RE | 20 (40 μL) | 200 μL |  |
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| PCSK9-20-GO | 20 (40 μL) | 200 μL |  |
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| PCSK9-20-GR | 20 (40 μL) | 200 μL |  |
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| PCSK9-20-AQ | 20 (40 μL) | 200 μL |  |
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| PCSK9-20-DIG | 20 (40 μL) | 200 μL |  |
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| PCSK9-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Details
Gene Symbol: PCSK9
Gene Name: Proprotein Convertase Subtilisin/kexin Type 9
Chromosome: CHR1: 55505148-55530526
Locus: 1p32.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PCSK9 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PCSK9-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping