PABPN1 FISH Probe
The PABPN1 FISH probe is designed to hybridize to the PABPN1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PABPN1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| PABPN1-20-RE | 20 (40 μL) | 200 μL |  |
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| PABPN1-20-GO | 20 (40 μL) | 200 μL |  |
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| PABPN1-20-GR | 20 (40 μL) | 200 μL |  |
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| PABPN1-20-AQ | 20 (40 μL) | 200 μL |  |
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| PABPN1-20-DIG | 20 (40 μL) | 200 μL |  |
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| PABPN1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]
Gene Details
Gene Symbol: PABPN1
Gene Name: Poly(A) Binding Protein Nuclear 1
Chromosome: CHR14: 23789396-23795394
Locus: 14q11.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: PABPN1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: PABPN1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping