NCSTN FISH Probe
The NCSTN FISH probe is designed to hybridize to the NCSTN gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NCSTN-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NCSTN-20-RE | 20 (40 μL) | 200 μL |  |
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| NCSTN-20-GO | 20 (40 μL) | 200 μL |  |
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| NCSTN-20-GR | 20 (40 μL) | 200 μL |  |
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| NCSTN-20-AQ | 20 (40 μL) | 200 μL |  |
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| NCSTN-20-DIG | 20 (40 μL) | 200 μL |  |
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| NCSTN-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Gene Details
Gene Symbol: NCSTN
Gene Name: Nicastrin
Chromosome: CHR1: 160313062-160328742
Locus: 1q23.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NCSTN FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NCSTN-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping