NCF4 FISH Probe
The NCF4 FISH probe is designed to hybridize to the NCF4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NCF4-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| NCF4-20-RE | 20 (40 μL) | 200 μL |  |
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| NCF4-20-GO | 20 (40 μL) | 200 μL |  |
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| NCF4-20-GR | 20 (40 μL) | 200 μL |  |
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| NCF4-20-AQ | 20 (40 μL) | 200 μL |  |
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| NCF4-20-DIG | 20 (40 μL) | 200 μL |  |
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| NCF4-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: NCF4
Gene Name: Neutrophil Cytosolic Factor 4
Chromosome: CHR22: 37257029-37274059
Locus: 22q12.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: NCF4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: NCF4-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping