MVB12B FISH Probe
The MVB12B FISH probe is designed to hybridize to the MVB12B gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MVB12B-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-RE | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-GO | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-GR | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-AQ | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-DIG | 20 (40 μL) | 200 μL |  |
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| MVB12B-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Details
Gene Symbol: MVB12B
Gene Name: Multivesicular Body Subunit 12B
Chromosome: CHR9: 126326843-126507040
Locus: 9q33.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MVB12B FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MVB12B-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping