MRPS12 FISH Probe
The MRPS12 FISH probe is designed to hybridize to the MRPS12 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MRPS12-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MRPS12-20-RE | 20 (40 μL) | 200 μL |  |
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| MRPS12-20-GO | 20 (40 μL) | 200 μL |  |
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| MRPS12-20-GR | 20 (40 μL) | 200 μL |  |
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| MRPS12-20-AQ | 20 (40 μL) | 200 μL |  |
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| MRPS12-20-DIG | 20 (40 μL) | 200 μL |  |
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| MRPS12-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MRPS12
Gene Name: Mitochondrial Ribosomal Protein S12
Chromosome: CHR19: 39421347-39423659
Locus: 19q13.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MRPS12 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MRPS12-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping