MLH1 FISH Probe
The MLH1 FISH probe is designed to hybridize to the MLH1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MLH1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MLH1-20-RE | 20 (40 μL) | 200 μL |  |
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| MLH1-20-GO | 20 (40 μL) | 200 μL |  |
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| MLH1-20-GR | 20 (40 μL) | 200 μL |  |
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| MLH1-20-AQ | 20 (40 μL) | 200 μL |  |
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| MLH1-20-DIG | 20 (40 μL) | 200 μL |  |
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| MLH1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: MLH1
Gene Name: MutL Homolog 1
Chromosome: CHR3: 37034840-37092337
Locus: 3p22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MLH1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MLH1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping