MHC FISH Probe
The MHC FISH probe is designed to hybridize to the MHC gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-C-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HLA-C-20-RE | 20 (40 μL) | 200 μL |  |
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| HLA-C-20-GO | 20 (40 μL) | 200 μL |  |
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| HLA-C-20-GR | 20 (40 μL) | 200 μL |  |
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| HLA-C-20-AQ | 20 (40 μL) | 200 μL |  |
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| HLA-C-20-DIG | 20 (40 μL) | 200 μL |  |
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| HLA-C-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLA-C
Gene Name: Major Histocompatibility Complex, Class I, C
Chromosome: CHR6: 31236525-31239913
Locus: 6p21.33
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: MHC FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-C-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping