LATS ( FISH Probe
The LATS ( FISH probe is designed to hybridize to the LATS ( gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| LATS1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| LATS1-20-RE | 20 (40 μL) | 200 μL |  |
|
| LATS1-20-GO | 20 (40 μL) | 200 μL |  |
|
| LATS1-20-GR | 20 (40 μL) | 200 μL |  |
|
| LATS1-20-AQ | 20 (40 μL) | 200 μL |  |
|
| LATS1-20-DIG | 20 (40 μL) | 200 μL |  |
|
| LATS1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Gene Details
Gene Symbol: LATS1
Gene Name: Large Tumor Suppressor Kinase 1
Chromosome: CHR6: 149982050-150039392
Locus: 6q25.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: LATS ( FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: LATS1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping