KRP FISH Probe
The KRP FISH probe is designed to hybridize to the KRP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYLK-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| MYLK-20-RE | 20 (40 μL) | 200 μL |  |
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| MYLK-20-GO | 20 (40 μL) | 200 μL |  |
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| MYLK-20-GR | 20 (40 μL) | 200 μL |  |
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| MYLK-20-AQ | 20 (40 μL) | 200 μL |  |
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| MYLK-20-DIG | 20 (40 μL) | 200 μL |  |
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| MYLK-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: MYLK
Gene Name: Myosin Light Chain Kinase
Chromosome: CHR3: 123331142-123603149
Locus: 3q21.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: KRP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: MYLK-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping