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KRAS FISH Probe

The KRAS FISH probe is designed to hybridize to the KRAS gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

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Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
KRAS-20-OR  (Standard Design) 20 (40 μL) 200 μL
KRAS-20-RE 20 (40 μL) 200 μL
KRAS-20-GO 20 (40 μL) 200 μL
KRAS-20-GR 20 (40 μL) 200 μL
KRAS-20-AQ 20 (40 μL) 200 μL
KRAS-20-DIG 20 (40 μL) 200 μL
KRAS-20-BIO 20 (40 μL) 200 μL

Gene Summary

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: KRAS

Gene Name: KRAS Proto-oncogene, GTPase

Chromosome: CHR12: 25358179-25403854

Locus: 12p12.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

A Clinicopathologic and Molecular Analysis of 34 Mediastinal Germ Cell Tumors Suggesting Different Modes of Teratoma Development

Mediastinal teratomas can be both malignant and benign. Increased 12p copy numbers are uniform in malignant testicular germ cell tumors (GCT), so the 12p copy numbers were analyzed in mediastinal GCTs to see if this is indicative of malignancy. FISH analysis was used with our KRAS and chromosome 12 centromere probes to look for 12p copy number increases. The sensitivity for increased 12p copies for malignant GCT was 69%. This is less than reports for other tumors, and a negative test for increased 12p copies should not necessarily rule out malignancy.
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Product Details

Product: KRAS FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: KRAS-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping