INSIG-1 FISH Probe
The INSIG-1 FISH probe is designed to hybridize to the INSIG-1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| INSIG1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| INSIG1-20-RE | 20 (40 μL) | 200 μL |  |
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| INSIG1-20-GO | 20 (40 μL) | 200 μL |  |
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| INSIG1-20-GR | 20 (40 μL) | 200 μL |  |
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| INSIG1-20-AQ | 20 (40 μL) | 200 μL |  |
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| INSIG1-20-DIG | 20 (40 μL) | 200 μL |  |
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| INSIG1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Details
Gene Symbol: INSIG1
Gene Name: Insulin Induced Gene 1
Chromosome: CHR7: 155089485-155101945
Locus: 7q36.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: INSIG-1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: INSIG1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping