INPP5D FISH Probe
The INPP5D FISH probe is designed to hybridize to the INPP5D gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| INPP5D-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| INPP5D-20-RE | 20 (40 μL) | 200 μL |  |
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| INPP5D-20-GO | 20 (40 μL) | 200 μL |  |
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| INPP5D-20-GR | 20 (40 μL) | 200 μL |  |
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| INPP5D-20-AQ | 20 (40 μL) | 200 μL |  |
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| INPP5D-20-DIG | 20 (40 μL) | 200 μL |  |
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| INPP5D-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Details
Gene Symbol: INPP5D
Gene Name: Inositol Polyphosphate-5-phosphatase D
Chromosome: CHR2: 233925035-234116549
Locus: 2q37.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: INPP5D FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: INPP5D-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping