IMP 1 FISH Probe
The IMP 1 FISH probe is designed to hybridize to the IMP 1 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IMPA1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IMPA1-20-RE | 20 (40 μL) | 200 μL |  |
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| IMPA1-20-GO | 20 (40 μL) | 200 μL |  |
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| IMPA1-20-GR | 20 (40 μL) | 200 μL |  |
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| IMPA1-20-AQ | 20 (40 μL) | 200 μL |  |
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| IMPA1-20-DIG | 20 (40 μL) | 200 μL |  |
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| IMPA1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Gene Details
Gene Symbol: IMPA1
Gene Name: Inositol Monophosphatase 1
Chromosome: CHR8: 82569150-82598589
Locus: 8q21.13
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IMP 1 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IMPA1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping