IL-4R FISH Probe
The IL-4R FISH probe is designed to hybridize to the IL-4R gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL4R-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IL4R-20-RE | 20 (40 μL) | 200 μL |  |
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| IL4R-20-GO | 20 (40 μL) | 200 μL |  |
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| IL4R-20-GR | 20 (40 μL) | 200 μL |  |
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| IL4R-20-AQ | 20 (40 μL) | 200 μL |  |
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| IL4R-20-DIG | 20 (40 μL) | 200 μL |  |
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| IL4R-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Details
Gene Symbol: IL4R
Gene Name: Interleukin 4 Receptor
Chromosome: CHR16: 27325250-27376099
Locus: 16p12.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IL-4R FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IL4R-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping