IGL FISH Probe
The IGL FISH probe is designed to hybridize to the IGL gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IGL-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| IGL-20-RE | 20 (40 μL) | 200 μL |  |
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| IGL-20-GO | 20 (40 μL) | 200 μL |  |
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| IGL-20-GR | 20 (40 μL) | 200 μL |  |
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| IGL-20-AQ | 20 (40 μL) | 200 μL |  |
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| IGL-20-DIG | 20 (40 μL) | 200 μL |  |
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| IGL-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: IGL
Gene Name: Immunoglobulin Lambda Locus
Chromosome: CHR22: 22026075-22922912
Locus: 22q11.22
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: IGL FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: IGL-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping