HSPG2 FISH Probe
The HSPG2 FISH probe is designed to hybridize to the HSPG2 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HSPG2-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HSPG2-20-RE | 20 (40 μL) | 200 μL |  |
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| HSPG2-20-GO | 20 (40 μL) | 200 μL |  |
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| HSPG2-20-GR | 20 (40 μL) | 200 μL |  |
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| HSPG2-20-AQ | 20 (40 μL) | 200 μL |  |
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| HSPG2-20-DIG | 20 (40 μL) | 200 μL |  |
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| HSPG2-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: HSPG2
Gene Name: Heparan Sulfate Proteoglycan 2
Chromosome: CHR1: 22148736-22263750
Locus: 1p36.12
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HSPG2 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HSPG2-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping