HP FISH Probe
The HP FISH probe is designed to hybridize to the HP gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HP-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HP-20-RE | 20 (40 μL) | 200 μL |  |
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| HP-20-GO | 20 (40 μL) | 200 μL |  |
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| HP-20-GR | 20 (40 μL) | 200 μL |  |
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| HP-20-AQ | 20 (40 μL) | 200 μL |  |
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| HP-20-DIG | 20 (40 μL) | 200 μL |  |
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| HP-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Gene Details
Gene Symbol: HP
Gene Name: Haptoglobin
Chromosome: CHR16: 72088507-72094955
Locus: 16q22.2
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HP FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HP-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping