HMWK FISH Probe
The HMWK FISH probe is designed to hybridize to the HMWK gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KNG1-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| KNG1-20-RE | 20 (40 μL) | 200 μL |  |
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| KNG1-20-GO | 20 (40 μL) | 200 μL |  |
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| KNG1-20-GR | 20 (40 μL) | 200 μL |  |
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| KNG1-20-AQ | 20 (40 μL) | 200 μL |  |
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| KNG1-20-DIG | 20 (40 μL) | 200 μL |  |
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| KNG1-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]
Gene Details
Gene Symbol: KNG1
Gene Name: Kininogen 1
Chromosome: CHR3: 186435097-186462199
Locus: 3q27.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HMWK FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: KNG1-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping