HLA-5.4 FISH Probe
The HLA-5.4 FISH probe is designed to hybridize to the HLA-5.4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-F-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HLA-F-20-RE | 20 (40 μL) | 200 μL |  |
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| HLA-F-20-GO | 20 (40 μL) | 200 μL |  |
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| HLA-F-20-GR | 20 (40 μL) | 200 μL |  |
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| HLA-F-20-AQ | 20 (40 μL) | 200 μL |  |
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| HLA-F-20-DIG | 20 (40 μL) | 200 μL |  |
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| HLA-F-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLA-F
Gene Name: Major Histocompatibility Complex, Class I, F
Chromosome: CHR6_mcf_hap5: 991650-1359214
Locus: 6p22.1
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HLA-5.4 FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-F-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping