HLA FISH Probe
The HLA FISH probe is designed to hybridize to the HLA gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HLA-DOB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
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| HLA-DOB-20-RE | 20 (40 μL) | 200 μL |  |
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| HLA-DOB-20-GO | 20 (40 μL) | 200 μL |  |
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| HLA-DOB-20-GR | 20 (40 μL) | 200 μL |  |
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| HLA-DOB-20-AQ | 20 (40 μL) | 200 μL |  |
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| HLA-DOB-20-DIG | 20 (40 μL) | 200 μL |  |
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| HLA-DOB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Details
Gene Symbol: HLA-DOB
Gene Name: Major Histocompatibility Complex, Class II, DO Beta
Chromosome: CHR6_ssto_hap7: 4211472-4215758
Locus: 6p21.32
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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Customer Publications
Product Details
Product: HLA FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HLA-DOB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping