HEXB FISH Probe
The HEXB FISH probe is designed to hybridize to the HEXB gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, prices are subject to change.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HEXB-20-OR (Standard Design) | 20 (40 μL) | 200 μL |  |
|
| HEXB-20-RE | 20 (40 μL) | 200 μL |  |
|
| HEXB-20-GO | 20 (40 μL) | 200 μL |  |
|
| HEXB-20-GR | 20 (40 μL) | 200 μL |  |
|
| HEXB-20-AQ | 20 (40 μL) | 200 μL |  |
|
| HEXB-20-DIG | 20 (40 μL) | 200 μL |  |
|
| HEXB-20-BIO | 20 (40 μL) | 200 μL |  |
Gene Summary
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Details
Gene Symbol: HEXB
Gene Name: Hexosaminidase Subunit Beta
Chromosome: CHR5: 73980968-74017113
Locus: 5q13.3
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|
Customer Publications
Product Details
Product: HEXB FISH Probe
Test Kits: 20 (40 μL)
ISH Buffer: 200 μL
SKU: HEXB-20-OR
Material Safety Data Sheet: MSDS.pdf
Turnaround Time: 7-10 Business Days
Shipping Time: 1-2 Day Expedited Shipping